Michael Parker

London

Director of Operations at The Conversation UK

News and features journalist, photographer, marionette ... Membership Editor at @conversationuk https://t.co/g15iOzNVij

Articles

A Hyperbolic Sum Rule for Probability: Solving Recursive (“Chicken and Egg”) Problems

4 weeks ago | mdpi.com | Michael Parker |Chris Jeynes |Stuart Walker

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Artificial intelligence for modelling infectious disease epidemics - Nature

2 months ago | nature.com | Serina Chang |Samantha Vanderslott |Elizaveta Semenova |Oliver Watson |Abhishek Dasgupta |Samuel V. Scarpino | +14 more

AbstractInfectious disease threats to individual and public health are numerous, varied and frequently unexpected. Artificial intelligence (AI) and related technologies, which are already supporting human decision making in economics, medicine and social science, have the potential to transform the scope and power of infectious disease epidemiology.
A Ratio Estimator for the Mean Using a Mixture Optional Enhance Trust (MOET) Randomized Response Model

Nov 20, 2024 | mdpi.com | Sat Gupta |Michael Parker |Sadia Khalil

1. IntroductionResearchers in disciplines as far-flung as business, public health, and psychology need answers to questions that are hard to obtain, because they involve sensitive personal information. In such scenarios, “social desirability bias” comes into play. Latkin et al. (2017) describe SDB as the tendency of respondents to underreport socially undesirable attitudes or behaviors and to overreport more desirable attributes [1].
Golgi-localized Ring Finger Protein 121 is necessary for MYCN-driven neuroblastoma tumorigenesis - Communications Biology

Oct 13, 2024 | nature.com | Belamy B. Cheung |Qian Wang |Janith A. Seneviratne |Andrew Gifford |Chelsea Mayoh |Lin Luo | +8 more

AbstractMYCN amplification predicts poor prognosis in childhood neuroblastoma. To identify MYCN oncogenic signal dependencies we performed N-ethyl-N-nitrosourea (ENU) mutagenesis on the germline of neuroblastoma-prone TH-MYCN transgenic mice to generate founders which had lost tumorigenesis. Sequencing of the mutant mouse genomes identified the Ring Finger Protein 121 (RNF121WT) gene mutated to RNFM158R associated with heritable loss of tumorigenicity.
Bioethics and the value of disagreement

Aug 31, 2024 | jme.bmj.com | Michael Parker

cultural diversityethicsMy work with the Global Health Bioethics Network has been an important ongoing reminder that bioethics means different things in different places and is practised in very many different ways.1 Partly despite this and to a large extent because of it, bioethics is uniquely positioned to contribute to addressing the pressing challenges posed by value polarisation and conflict in increasingly complex, diverse and interconnected societies.
The Integral Nature of the Scientific Enterprise

Aug 23, 2024 | preprints.org | Chris Jeynes |Michael Parker

PreprintArticleVersion 1This version is not peer-reviewedVersion 1: Received: 21 August 2024 / Approved: 22 August 2024 / Online: 23 August 2024 (11:04:01 CEST)Jeynes, C.; Parker, M. C. The Integral Nature of the Scientific Enterprise. Preprints 2024, 2024081674. https://doi.org/10.20944/preprints202408.1674.v1Jeynes, C.; Parker, M. C. The Integral Nature of the Scientific Enterprise. Preprints 2024, 2024081674.
Global health photography behind the façade of empowerment and decolonisation

Aug 23, 2024 | tandfonline.com | Jonathan Shaffer |Sonya de Laat |Michael Parker |Patricia Kingori

ABSTRACTGlobal health photography has historically been commissioned and, therefore, dominated by the gaze of Western photographers on assignments in the Global South. This is changing as part of international calls to decolonise global health and stimulate ‘empowerment’, spawning a growing initiative to hire local photographers. This article, based on interviews with global health photographers, reflects on this paradigm shift.
A Hyperbolic Sum Rule for Probability: Solving Recursive (“Chicken & Egg”) Problems

Jul 22, 2024 | preprints.org | Michael Parker |Chris Jeynes |Stuart Walker

PreprintArticleVersion 1This version is not peer-reviewedVersion 1: Received: 20 July 2024 / Approved: 20 July 2024 / Online: 22 July 2024 (09:57:16 CEST)Parker, M. C.; Jeynes, C.; Walker, S. D. A Hyperbolic Sum Rule for Probability: Solving Recursive (“Chicken & Egg”) Problems. Preprints 2024, 2024071660. https://doi.org/10.20944/preprints202407.1660.v1Parker, M. C.; Jeynes, C.; Walker, S. D. A Hyperbolic Sum Rule for Probability: Solving Recursive (“Chicken & Egg”) Problems. Preprints 2024, 2024071660.
Vγ9Vδ2 T cells recognize butyrophilin 2A1 and 3A1 heteromers - Nature Immunology

Jul 16, 2024 | nature.com | Thomas S. Fulford |Marc Rigau |Amy Chung |Michael Parker |Andreas Behren |Nicholas A. Gherardin | +1 more

AbstractButyrophilin (BTN) molecules are emerging as key regulators of T cell immunity; however, how they trigger cell-mediated responses is poorly understood. Here, the crystal structure of a gamma-delta T cell antigen receptor (γδTCR) in complex with BTN2A1 revealed that BTN2A1 engages the side of the γδTCR, leaving the apical TCR surface bioavailable. We reveal that a second γδTCR ligand co-engages γδTCR via binding to this accessible apical surface in a BTN3A1-dependent manner.
Ethical implications of disparities in translation genomic medicine: from research to practice

Jun 21, 2024 | jme.bmj.com | Mehrunisha Suleman |Michael Parker |Nadeem Mumtaz Qureshi

Ethical implications of disparities in translation genomic medicine: from research to practice Free Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.