Nicholas A. Gherardin

Jul 16, 2024 | nature.com | Thomas S. Fulford |Marc Rigau |Amy Chung |Michael Parker |Andreas Behren |Nicholas A. Gherardin | +1 more

AbstractButyrophilin (BTN) molecules are emerging as key regulators of T cell immunity; however, how they trigger cell-mediated responses is poorly understood. Here, the crystal structure of a gamma-delta T cell antigen receptor (γδTCR) in complex with BTN2A1 revealed that BTN2A1 engages the side of the γδTCR, leaving the apical TCR surface bioavailable. We reveal that a second γδTCR ligand co-engages γδTCR via binding to this accessible apical surface in a BTN3A1-dependent manner.