Andrew Earl

Jul 24, 2024 | trcp.org | Noah Davis |Madeleine West |Liz Rose |Andrew Earl

May 20, 2024 | nature.com | Giulia Schiroli |Fabiana M. Duarte |Andrew Earl |Jason D. Buenrostro

AbstractHematopoietic stem cell (HSC) mutations can result in clonal hematopoiesis (CH) with heterogeneous clinical outcomes. Here, we investigate how the cell state preceding Tet2 mutation impacts the pre-malignant phenotype. Using an inducible system for clonal analysis of myeloid progenitors, we find that the epigenetic features of clones at similar differentiation status are highly heterogeneous and functionally respond differently to Tet2 mutation.

Jan 17, 2024 | trcp.org | Jon Holst |Jen Leahy |Andrew Earl

TRCP Responds to BLM Western Solar Development Proposal Organization encourages BLM to conserve big game habitats & hunting and fishing areas as it advances solar development on public lands Today, the Bureau of Land Management released a draft plan that—when completed—will guide utility-scale solar development on federal public lands across 11 western states. The draft is a proposed update of BLM’s 2012 Western Solar Plan, which identified areas in Arizona, California, Colorado, Nevada, New...

Jan 16, 2024 | trcp.org | Ryan Lockwood |Ian Nakayama |Andrew Earl

Hunting in the Everglades? Yes, That’s a Thing When you think of the Everglades, you probably think of water. Of airboats and alligators, miles of submerged sawgrass and cypress domes. Of swamps filled with mosquitos and invasive pythons.

Apr 27, 2023 | nature.com | Haiqi Chen |Andrew Earl |Jason D. Buenrostro

AbstractIn biological systems, spatial organization and function are interconnected. Here we present photoselective sequencing, a new method for genomic and epigenomic profiling within morphologically distinct regions. Starting with an intact biological specimen, photoselective sequencing uses targeted illumination to selectively unblock a photocaged fragment library, restricting the sequencing-based readout to microscopically identified spatial regions.