Fabiana M. Duarte

May 20, 2024 | nature.com | Giulia Schiroli |Fabiana M. Duarte |Andrew Earl |Jason D. Buenrostro

AbstractHematopoietic stem cell (HSC) mutations can result in clonal hematopoiesis (CH) with heterogeneous clinical outcomes. Here, we investigate how the cell state preceding Tet2 mutation impacts the pre-malignant phenotype. Using an inducible system for clonal analysis of myeloid progenitors, we find that the epigenetic features of clones at similar differentiation status are highly heterogeneous and functionally respond differently to Tet2 mutation.

Aug 3, 2023 | nature.com | Ginevra Caratu |Orit Rozenblatt-Rosen |Wendy Luo |Christoph Muus |Fabiana M. Duarte |M. Ryan Corces | +19 more

AbstractSingle-cell assay for transposase-accessible chromatin by sequencing (scATAC-seq) has emerged as a powerful tool for dissecting regulatory landscapes and cellular heterogeneity. However, an exploration of systemic biases among scATAC-seq technologies has remained absent.