Giulia Schiroli

May 20, 2024 | nature.com | Giulia Schiroli |Fabiana M. Duarte |Andrew Earl |Jason D. Buenrostro

AbstractHematopoietic stem cell (HSC) mutations can result in clonal hematopoiesis (CH) with heterogeneous clinical outcomes. Here, we investigate how the cell state preceding Tet2 mutation impacts the pre-malignant phenotype. Using an inducible system for clonal analysis of myeloid progenitors, we find that the epigenetic features of clones at similar differentiation status are highly heterogeneous and functionally respond differently to Tet2 mutation.