Anusri Pampari

May 29, 2024 | biorxiv.org | Sahin Naqvi |Seungsoo Kim |Saman Tabatabaee |Anusri Pampari

AbstractDeep learning approaches have made significant advances in predicting cell type-specific chromatin patterns from the identity and arrangement of transcription factor (TF) binding motifs. However, most models have been applied in unperturbed contexts, precluding a predictive understanding of how chromatin state responds to TF perturbation.

Oct 21, 2023 | biorxiv.org | Surag Nair |Mohamed Ameen |Laksshman Sundaram |Anusri Pampari

AbstractEctopic expression of OCT4, SOX2, KLF4 and MYC (OSKM) transforms differentiated cells into induced pluripotent stem cells. To refine our mechanistic understanding of reprogramming, especially during the early stages, we profiled chromatin accessibility and gene expression at single-cell resolution across a densely sampled time course of human fibroblast reprogramming.

Oct 4, 2023 | biorxiv.org | Surag Nair |Mohamed Ameen |Laksshman Sundaram |Anusri Pampari

AbstractEctopic expression of OCT4, SOX2, KLF4 and MYC (OSKM) transforms differentiated cells into induced pluripotent stem cells. To refine our mechanistic understanding of reprogramming, especially during the early stages, we profiled chromatin accessibility and gene expression at single-cell resolution across a finely sampled time course of human fibroblast reprogramming.