Arminja N. Kettenbach

Dec 19, 2024 | cell.com | Jessica Kelley |Emilia Dimitrova |Hieu Nguyen |Hiếu Nguyễn |Aleksander T Szczurek |Amy Hughes | +4 more

Nov 8, 2024 | nature.com | Arminja N. Kettenbach |Jakob Nilsson

AbstractPlk1 is a key mitotic kinase that localizes to distinct subcellular structures to promote accurate mitotic progression. Plk1 recruitment depends on direct interaction between polo-box domain (PBD) on Plk1 and PBD binding motif (PBD BM) on the interactors. However, recent study showed that PBD BM alone is not enough for stable binding between CENP-U and Plk1 highlighting the complexity of the interaction which warrants further investigation.

Jun 8, 2023 | nature.com | Bin Wang |Arminja N. Kettenbach

AbstractIn the Neurospora circadian system, the White Collar Complex (WCC) drives expression of the principal circadian negative arm component frequency (frq). FRQ interacts with FRH (FRQ-interacting RNA helicase) and CKI, forming a stable complex that represses its own expression by inhibiting WCC. In this study, a genetic screen identified a gene, designated as brd-8, that encodes a conserved auxiliary subunit of the NuA4 histone acetylation complex.

Apr 24, 2023 | biorxiv.org | Bin Wang |Xiaoying Zhou |Arminja N. Kettenbach |Hugh Mitchell

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