Arminja N. Kettenbach

2 months ago | nature.com | Melina Klostermann |Rainer Will |Dominic Helm |Kathi Zarnack |Sven Diederichs |Arminja N. Kettenbach | +1 more

AbstractRibonucleoprotein complexes are dynamic assemblies of RNA with RNA-binding proteins, which modulate the fate of RNA. Inversely, RNA riboregulates the interactions and functions of the associated proteins. Dysregulation of ribonucleoprotein functions is linked to diseases such as cancer and neurological disorders. In dividing cells, RNA and RNA-binding proteins are present in mitotic structures, but their impact on cell division remains unclear.

Dec 19, 2024 | cell.com | Jessica Kelley |Emilia Dimitrova |Hieu Nguyen |Hiếu Nguyễn |Aleksander T Szczurek |Amy Hughes | +4 more

Nov 8, 2024 | nature.com | Arminja N. Kettenbach |Jakob Nilsson

AbstractPlk1 is a key mitotic kinase that localizes to distinct subcellular structures to promote accurate mitotic progression. Plk1 recruitment depends on direct interaction between polo-box domain (PBD) on Plk1 and PBD binding motif (PBD BM) on the interactors. However, recent study showed that PBD BM alone is not enough for stable binding between CENP-U and Plk1 highlighting the complexity of the interaction which warrants further investigation.

Jun 8, 2023 | nature.com | Bin Wang |Arminja N. Kettenbach

AbstractIn the Neurospora circadian system, the White Collar Complex (WCC) drives expression of the principal circadian negative arm component frequency (frq). FRQ interacts with FRH (FRQ-interacting RNA helicase) and CKI, forming a stable complex that represses its own expression by inhibiting WCC. In this study, a genetic screen identified a gene, designated as brd-8, that encodes a conserved auxiliary subunit of the NuA4 histone acetylation complex.

Apr 24, 2023 | biorxiv.org | Bin Wang |Xiaoying Zhou |Arminja N. Kettenbach |Hugh Mitchell

Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.