Rainer Will

Aug 28, 2024 | mdpi.com | Yuan Xiao Zhu |Su Na Kim |Rainer Will |Zhong-Rong Chen

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.

Feb 6, 2024 | nature.com | Ling Hai |Dirk C Hoffmann |Julien Hiblot |Philipp Sievers |Miriam Ratliff |Kati J. Ernst | +6 more

AbstractTumor microtubes (TMs) connect glioma cells to a network with considerable relevance for tumor progression and therapy resistance. However, the determination of TM-interconnectivity in individual tumors is challenging and the impact on patient survival unresolved.

Dec 1, 2023 | nature.com | Lukas Beumers |Efstathios-Iason Vlachavas |Luisa Schwarzmüller |Birgitta E. Michels |Emre Sofyali |Yosef Yarden | +2 more

AbstractIntratumoral heterogeneity impacts the success or failure of anti-cancer therapies. Here, we investigated the evolution and mechanistic heterogeneity in clonal populations of cell models for estrogen receptor positive breast cancer. To this end, we established barcoded models of luminal breast cancer and rendered them resistant to commonly applied first line endocrine therapies.