Arnold R. Kriegstein

Dec 9, 2024 | nature.com | Paola Arlotta |Helen S. Bateup |J. Gray Camp |Silvia Cappello |Fred Gage |Jürgen A. Knoblich | +13 more

AbstractAs the field of neural organoids and assembloids rapidly expands, there is an emergent need for guidance and advice on designing, conducting and reporting experiments to increase the reproducibility and utility of these models.

Sep 30, 2024 | nature.com | Elizabeth Crouch |Kyle Jacobs |Lakyn Mayo |Jennifer Choi |Saba Shaikh |Arnold R. Kriegstein | +4 more

AbstractGerminal matrix hemorrhage (GMH) is a devastating neurodevelopmental condition affecting preterm infants, but why blood vessels in this brain region are vulnerable to rupture remains unknown. Here we show that microglia in prenatal mouse and human brain interact with nascent vasculature in an age-dependent manner and that ablation of these cells in mice reduces angiogenesis in the ganglionic eminences, which correspond to the human germinal matrix.

Feb 28, 2023 | journals.plos.org | Li Wang |Arnold R. Kriegstein

Radial glial cells (RGCs) are neural stem cells in the developing cerebral cortex responsible for producing neurons and glia. They have an elongated bipolar morphology that spans the thickness of the developing cortex. RGC somata are located in the ventricular zone and connect to the ventricle through apical endfeet (Fig 1). On the basal side, they extend a long basal fiber that contacts the basement membrane in the pia matter through basal endfeet (Fig 1).