Bernard Ng

Aug 13, 2024 | medrxiv.org | Bernard Ng |Julie Schneider |Aron S. Buchman |Ricardo A Vialle

The authors have declared no competing interest. This work has been supported the following National Institute on Aging (NIA) grants: P30AG10161 (DAB), P30AG72975 (JAS), R01AG15819 (DAB), R01AG17917 (DAB), U01AG46152 (PLD, DAB), U01AG61356 (PLD, DAB), R01AG22018 (LLL), U01AG079847 (CG). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Mar 21, 2024 | nature.com | Lu Zeng |Bernard Ng |Hyo Jung Lee |Atlas Khan |Badri Vardarajan |Krzysztof Kiryluk | +9 more

AbstractThe relationship between genetic variation and gene expression in brain cell types and subtypes remains understudied. Here, we generated single-nucleus RNA sequencing data from the neocortex of 424 individuals of advanced age; we assessed the effect of genetic variants on RNA expression in cis (cis-expression quantitative trait loci) for seven cell types and 64 cell subtypes using 1.5 million transcriptomes.