Atsushi Kumanogoh

Aug 1, 2024 | jrheum.org | Yasutaka Okita |Masashi Okamoto |Jun Fujimoto |Atsushi Kumanogoh

Granulomatosis with polyangiitis (GPA) is a systemic autoimmune disease that causes necrotizing vasculitis of small- to medium-sized blood vessels and necrotizing granulomatous inflammation, primarily of the upper and lower respiratory system. A 33-year-old woman presented with a 16-month history of headaches, nasal obstruction, and anosmia.

Jun 24, 2024 | nature.com | Masayuki Nishide |Atsushi Kumanogoh

AbstractSince the advent of single-cell RNA sequencing (scRNA-seq) methodology, single-cell analysis has become a powerful tool for exploration of cellular networks and dysregulated immune responses in disease pathogenesis. Advanced bioinformatics tools have enabled the combined analysis of scRNA-seq data and information on various cell properties, such as cell surface molecular profiles, chromatin accessibility and spatial information, leading to a deeper understanding of pathology.

Apr 27, 2024 | medrxiv.org | Yoshiya Tanaka |Atsushi Kumanogoh |Tatsuya Atsumi |Tomonori Ishii

COMPETING INTERESTS: YT has received grants from Mitsubishi-Tanabe, Eisai, Chugai, and Taisho; speaker fees and/or honoraria from Eli Lilly, AstraZeneca, Abbvie, Gilead, Chugai, Behringer-Ingelheim, GlaxoSmithKline, Eisai, Taisho, Bristol-Myers Squibb, Pfizer, and Taiho. AK has received grants from Chugai; consulting fees from Eisai; speaker fees and/or honoraria from Asahi Kasei, Astellas, Eisai, GlaxoSmithKline, Chugai, Eli Lilly, Boehringer-Ingelheim, Pfizer, and Bristol-Myers Squibb.

Feb 23, 2024 | jrheum.org | Yasutaka Okita |Masashi Okamoto |Atsushi Kumanogoh |Jun Fujimoto

Pneumocephalus and Cerebral Abscess in Granulomatosis With Polyangiitis Yasutaka Okita, Masashi Okamoto, Jun Fujimoto, Atsushi Kumanogoh The Journal of Rheumatology Mar 2024, jrheum.2023-1231; DOI: 10.3899/jrheum.2023-1231

Jan 31, 2024 | nature.com | Yuki Ishikawa |Nao Tanaka |Mitsuteru Akahoshi |Takashi Matsushita |Akira Oka |Motohisa Yamamoto | +15 more

AbstractHere we report the largest Asian genome-wide association study (GWAS) for systemic sclerosis performed to date, based on data from Japanese subjects and comprising of 1428 cases and 112,599 controls. The lead SNP is in the FCGR/FCRL region, which shows a penetrating association in the Asian population, while a complete linkage disequilibrium SNP, rs10917688, is found in a cis-regulatory element for IRF8.