Atsushi Kumanogoh

2 months ago | nature.com | Moto Yaga |Kentaro Fukushima |Hirohisa Nakamae |Satoshi Yoshihara |Haruhiko Kishima |Tsuyoshi Takiuchi | +5 more

AbstractAcute myeloid leukemia (AML)-specific target antigens are difficult to identify. Here we demonstrate that HLA-DRB1 can serve as a leukemia-specific target of chimeric antigen receptor (CAR) T cells in patients with AML after allogeneic hematopoietic stem cell transplantation (allo-HCT). We identified KG2032 as a monoclonal antibody specifically bound to AML cells in about half of patients, but not to normal leukocytes other than B lymphocytes.

Aug 1, 2024 | jrheum.org | Yasutaka Okita |Masashi Okamoto |Jun Fujimoto |Atsushi Kumanogoh

Granulomatosis with polyangiitis (GPA) is a systemic autoimmune disease that causes necrotizing vasculitis of small- to medium-sized blood vessels and necrotizing granulomatous inflammation, primarily of the upper and lower respiratory system. A 33-year-old woman presented with a 16-month history of headaches, nasal obstruction, and anosmia.

Jun 24, 2024 | nature.com | Masayuki Nishide |Atsushi Kumanogoh

AbstractSince the advent of single-cell RNA sequencing (scRNA-seq) methodology, single-cell analysis has become a powerful tool for exploration of cellular networks and dysregulated immune responses in disease pathogenesis. Advanced bioinformatics tools have enabled the combined analysis of scRNA-seq data and information on various cell properties, such as cell surface molecular profiles, chromatin accessibility and spatial information, leading to a deeper understanding of pathology.

Apr 27, 2024 | medrxiv.org | Yoshiya Tanaka |Atsushi Kumanogoh |Tatsuya Atsumi |Tomonori Ishii

COMPETING INTERESTS: YT has received grants from Mitsubishi-Tanabe, Eisai, Chugai, and Taisho; speaker fees and/or honoraria from Eli Lilly, AstraZeneca, Abbvie, Gilead, Chugai, Behringer-Ingelheim, GlaxoSmithKline, Eisai, Taisho, Bristol-Myers Squibb, Pfizer, and Taiho. AK has received grants from Chugai; consulting fees from Eisai; speaker fees and/or honoraria from Asahi Kasei, Astellas, Eisai, GlaxoSmithKline, Chugai, Eli Lilly, Boehringer-Ingelheim, Pfizer, and Bristol-Myers Squibb.

Feb 23, 2024 | jrheum.org | Yasutaka Okita |Masashi Okamoto |Atsushi Kumanogoh |Jun Fujimoto

Pneumocephalus and Cerebral Abscess in Granulomatosis With Polyangiitis Yasutaka Okita, Masashi Okamoto, Jun Fujimoto, Atsushi Kumanogoh The Journal of Rheumatology Mar 2024, jrheum.2023-1231; DOI: 10.3899/jrheum.2023-1231