Yuki Ishikawa

Oct 3, 2024 | nature.com | Satoshi Koyama |Xiaoxi Liu |Yoshinao Koike |Keiko Hikino |Masaru Koido |Wei Li | +13 more

AbstractHuman genetic variants are associated with many traits through largely unknown mechanisms. Here, combining approximately 260,000 Japanese study participants, a Japanese-specific genotype reference panel and statistical fine-mapping, we identified 4,423 significant loci across 63 quantitative traits, among which 601 were new, and 9,406 putatively causal variants.

Sep 13, 2024 | medrxiv.org | Yuki Ishikawa |Katsunori Ikari |Suguru Honda |Shunsuke Uchiyama

S.U., Y.I., K.I., S.H., K.H., E.T., and C.T. have no conflicts of interest. Y.K. has research grants from Takeda Pharmaceuticals. T.G. received speaking fees from Asahi Kasei Pharma, Astellas, Boehringer-Ingelheim, Bristol-Myers Squibb, Chugai, Eisai, Eli Lily, Gilead Sciences, Ono Pharmaceuticals, Pfizer, and Tanabe Mitsubishi. G.G. declared competing interests, and patent application PCT/WO2019/079493 has been filed for the mosaic chromosomal alteration detection method used in this study.

Jan 31, 2024 | nature.com | Yuki Ishikawa |Nao Tanaka |Mitsuteru Akahoshi |Takashi Matsushita |Akira Oka |Motohisa Yamamoto | +15 more

AbstractHere we report the largest Asian genome-wide association study (GWAS) for systemic sclerosis performed to date, based on data from Japanese subjects and comprising of 1428 cases and 112,599 controls. The lead SNP is in the FCGR/FCRL region, which shows a penetrating association in the Asian population, while a complete linkage disequilibrium SNP, rs10917688, is found in a cis-regulatory element for IRF8.

Oct 26, 2023 | biorxiv.org | Keisuke Imoto |Yuki Ishikawa |Yoshinori Aso |Jan Funke

AbstractAs observed in human language learning and song learning in birds, the fruit fly Drosophila melanogaster changes its' auditory behaviors according to prior sound experiences. Female flies that have heard male courtship songs of the same species are less responsive to courtship songs of different species.

Aug 23, 2023 | nature.com | Yuki Ishikawa |Rosalind A. Eeles |Yoshinao Koike |Keiko Hikino |Momoko Horikoshi |Kaoru Ito | +4 more

AbstractProstate cancer (PrCa) is the second most common cancer worldwide in males. While strongly warranted, the prediction of mortality risk due to PrCa, especially before its development, is challenging.