Rocky M. Barilla

Oct 16, 2024 | nature.com | Martin W. LaFleur |Rocky M. Barilla |Ayshwarya Subramanian |Yoon-Chul Kye |John G. Doench |Isaac M. Chiu | +2 more

AbstractThe balance between T helper type 1 (TH1) cells and other TH cells is critical for antiviral and anti-tumour responses1,2,3, but how this balance is achieved remains poorly understood. Here we dissected the dynamic regulation of TH1 cell differentiation during in vitro polarization, and during in vivo differentiation after acute viral infection.

Jun 21, 2023 | nature.com | Yoon-Chul Kye |Elena Torlai Triglia |Alexandra Schnell |Toni Delorey |Kanishka Mohib |Christopher J. Giuliano | +11 more

AbstractThe role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit tumour growth1,2. Here, using high-throughput flow cytometry as well as bulk and single-cell RNA-sequencing and B-cell-receptor-sequencing analysis of B cells temporally during B16F10 melanoma growth, we identified a subset of B cells that expands specifically in the draining lymph node over time in tumour-bearing mice.