Badri Vardarajan

Jun 20, 2024 | nature.com | Özkan İş |Xue Wang |Joseph S. Reddy |Yuhao Min |Elanur Yilmaz |Prabesh Bhattarai | +19 more

AbstractTo uncover molecular changes underlying blood-brain-barrier dysfunction in Alzheimer’s disease, we performed single nucleus RNA sequencing in 24 Alzheimer’s disease and control brains and focused on vascular and astrocyte clusters as main cell types of blood-brain-barrier gliovascular-unit. The majority of the vascular transcriptional changes were in pericytes.

Mar 21, 2024 | nature.com | Lu Zeng |Bernard Ng |Hyo Jung Lee |Atlas Khan |Badri Vardarajan |Krzysztof Kiryluk | +9 more

AbstractThe relationship between genetic variation and gene expression in brain cell types and subtypes remains understudied. Here, we generated single-nucleus RNA sequencing data from the neocortex of 424 individuals of advanced age; we assessed the effect of genetic variants on RNA expression in cis (cis-expression quantitative trait loci) for seven cell types and 64 cell subtypes using 1.5 million transcriptomes.