Lu Zeng

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Articles

Cell subtype-specific effects of genetic variation in the Alzheimer’s disease brain - Nature Genetics

Mar 21, 2024 | nature.com | Lu Zeng |Bernard Ng |Hyo Jung Lee |Atlas Khan |Badri Vardarajan |Krzysztof Kiryluk | +9 more

AbstractThe relationship between genetic variation and gene expression in brain cell types and subtypes remains understudied. Here, we generated single-nucleus RNA sequencing data from the neocortex of 424 individuals of advanced age; we assessed the effect of genetic variants on RNA expression in cis (cis-expression quantitative trait loci) for seven cell types and 64 cell subtypes using 1.5 million transcriptomes.

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