Krzysztof Kiryluk

Sep 13, 2024 | nature.com | Atlas Khan |Krzysztof Kiryluk

AbstractGenome-wide association studies (GWAS) have uncovered thousands of risk variants that individually have small effects on the risk of human diseases, including chronic kidney disease, type 2 diabetes, heart diseases and inflammatory disorders, but cumulatively explain a substantial fraction of disease risk, underscoring the complexity and pervasive polygenicity of common disorders. This complexity poses unique challenges to the clinical translation of GWAS findings.

Mar 21, 2024 | nature.com | Lu Zeng |Bernard Ng |Hyo Jung Lee |Atlas Khan |Badri Vardarajan |Krzysztof Kiryluk | +9 more

AbstractThe relationship between genetic variation and gene expression in brain cell types and subtypes remains understudied. Here, we generated single-nucleus RNA sequencing data from the neocortex of 424 individuals of advanced age; we assessed the effect of genetic variants on RNA expression in cis (cis-expression quantitative trait loci) for seven cell types and 64 cell subtypes using 1.5 million transcriptomes.