Nicholas C. Wu

Jan 15, 2025 | cell.com | Qi Wen Teo |Yiquan Wang |Huibin Lv |Michael S. Oade |Kevin J. Mao |Timothy J.C. Tan | +8 more

Keywordsinfluenza virusNS1nuclear export proteinNEPevolutionary constraintsthe transcription-to-replication switchinnate immune responsecellular apoptosismammalian adaptation of avian influenza virusResearch topic(s)CP: MicrobiologyCP: Molecular biologyIntroductionInfluenza A virus (IAV) belongs to the Orthomyxoviridae family and is characterized as an enveloped, negative-sense, single-stranded, segmented RNA virus.

Oct 21, 2024 | nature.com | Nicholas C. Wu |Susana Clusella-Trullas |Michael Kearney |Rafael Parelli Bovo |Urtzi Enriquez-Urzelai

AbstractCompared with the risks associated with climate warming and extremes, the risks of climate-induced drying to animal species remain understudied. This is particularly true for water-sensitive groups, such as anurans (frogs and toads), whose long-term survival must be considered in the context of both environmental changes and species sensitivity.

Aug 7, 2024 | msn.com | Nicholas C. Wu |Madison Fernandez |Ally Mutnick

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Jul 25, 2024 | msn.com | Liz Crampton |Nicholas C. Wu |Daniella Diaz |Sarah Ferris |Ursula Perano |Ben Lefebvre

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May 13, 2024 | nature.com | Ruipeng Lei |Enya Qing |Meng Yuan |Ian Wilson |Tom Gallagher |Stanley Perlman | +1 more

AbstractThe fusion peptide of SARS-CoV-2 spike protein is functionally important for membrane fusion during virus entry and is part of a broadly neutralizing epitope. However, sequence determinants at the fusion peptide and its adjacent regions for pathogenicity and antigenicity remain elusive.