Benoît Palancade

2 weeks ago | nature.com | Stéphane Pelletier |Virginie Marchand |Delphine Naquin |Jessica Andreani |Yuri Motorin |Benoît Palancade

AbstractSmall nucleolar RNAs are non-coding transcripts that guide chemical modifications of RNA substrates and modulate gene expression at the epigenetic and post-transcriptional levels. However, the extent of their regulatory potential and the underlying molecular mechanisms remain poorly understood. Here, we identify a conserved, previously unannotated intronic C/D-box snoRNA, termed snR107, hosted in the fission yeast long non-coding RNA mamRNA and carrying two independent cellular functions.

Apr 7, 2024 | nature.com | Carine D. Lefèvre |Raphaël M. Mangione |Batoul Farhat |Ismael Boussaid |Chloé Friedrich |Aurore Tourville | +21 more

AbstractMyelodysplastic syndromes (MDS) with mutated SF3B1 gene present features including a favourable outcome distinct from MDS with mutations in other splicing factor genes SRSF2 or U2AF1. Molecular bases of these divergences are poorly understood. Here we find that SF3B1-mutated MDS show reduced R-loop formation predominating in gene bodies associated with intron retention reduction, not found in U2AF1- or SRSF2-mutated MDS.