Beth Martin

May 9, 2024 | nature.com | Jean-Benoît Lalanne |Diego Calderon |Beth Martin |Choli Lee |Cole Trapnell

AbstractThe inability to scalably and precisely measure the activity of developmental cis-regulatory elements (CREs) in multicellular systems is a bottleneck in genomics. Here we develop a dual RNA cassette that decouples the detection and quantification tasks inherent to multiplex single-cell reporter assays. The resulting measurement of reporter expression is accurate over multiple orders of magnitude, with a precision approaching the limit set by Poisson counting noise.

Feb 14, 2024 | nature.com | Chengxiang Qiu |Beth Martin |Riza M. Daza |Megan Taylor |Olivia Fulton |Xinxian Deng | +6 more

AbstractThe house mouse (Mus musculus) is an exceptional model system, combining genetic tractability with close evolutionary affinity to humans1,2. Mouse gestation lasts only 3 weeks, during which the genome orchestrates the astonishing transformation of a single-cell zygote into a free-living pup composed of more than 500 million cells.