Beverly Naigles

Aug 27, 2024 | nature.com | Yu-Hang Xing |Rémi Buisson |Beverly Naigles |Mary Awad |Raffaele Renella |Edwin Choy | +2 more

AbstractEWS fusion oncoproteins underlie several human malignancies including Desmoplastic Small Round Cell Tumor (DSRCT), an aggressive cancer driven by EWS-WT1 fusion proteins. Here we combine chromatin occupancy and 3D profiles to identify EWS-WT1-dependent gene regulation networks and target genes. We show that EWS-WT1 is a powerful chromatin activator controlling an oncogenic gene expression program that characterizes primary tumors.

Sep 7, 2023 | jbc.org | Beverly Naigles |Jan Soroczynski

AbstractMacrophages must respond appropriately to pathogens and other pro-inflammatory stimuli in order to perform their roles in fighting infection. One way in which inflammatory stimuli can vary is in their dynamics – that is, the amplitude and duration of stimulus experienced by the cell. In this study, we performed long-term live cell imaging in a microfluidic device to investigate how the pro-inflammatory genes IRF1, CXCL10, and CXCL9 respond to dynamic interferon-gamma (IFNγ) stimulation.

May 22, 2023 | biorxiv.org | Avaneesh Narla |Lev Tsimring |Beverly Naigles |Jan Soroczynski

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