Yu-Hang Xing

Aug 27, 2024 | nature.com | Yu-Hang Xing |Rémi Buisson |Beverly Naigles |Mary Awad |Raffaele Renella |Edwin Choy | +2 more

AbstractEWS fusion oncoproteins underlie several human malignancies including Desmoplastic Small Round Cell Tumor (DSRCT), an aggressive cancer driven by EWS-WT1 fusion proteins. Here we combine chromatin occupancy and 3D profiles to identify EWS-WT1-dependent gene regulation networks and target genes. We show that EWS-WT1 is a powerful chromatin activator controlling an oncogenic gene expression program that characterizes primary tumors.

May 9, 2023 | frontiersin.org | Yu-Hang Xing |Yaming Li

1 IntroductionOsteoarthritis (OA) is a classic degenerative chronic disease with significant symptoms, including pain, morning stiffness, and joint instability, leading to disability and ultimately impairing quality of life (Martel-Pelletier et al., 2016). The incidence of osteoarthritis is still high worldwide, with approximately 303.1 million hip and knee osteoarthritis cases, according to the Global Burden of Disease Project (GBD).