Yu-Hang Xing

Aug 27, 2024 | nature.com | Yu-Hang Xing |Rémi Buisson |Beverly Naigles |Mary Awad |Raffaele Renella |Edwin Choy | +2 more

AbstractEWS fusion oncoproteins underlie several human malignancies including Desmoplastic Small Round Cell Tumor (DSRCT), an aggressive cancer driven by EWS-WT1 fusion proteins. Here we combine chromatin occupancy and 3D profiles to identify EWS-WT1-dependent gene regulation networks and target genes. We show that EWS-WT1 is a powerful chromatin activator controlling an oncogenic gene expression program that characterizes primary tumors.

May 9, 2023 | frontiersin.org | Yu-Hang Xing |Yaming Li

1 IntroductionOsteoarthritis (OA) is a classic degenerative chronic disease with significant symptoms, including pain, morning stiffness, and joint instability, leading to disability and ultimately impairing quality of life (Martel-Pelletier et al., 2016). The incidence of osteoarthritis is still high worldwide, with approximately 303.1 million hip and knee osteoarthritis cases, according to the Global Burden of Disease Project (GBD).

Apr 10, 2023 | nature.com | Yu-Hang Xing

AbstractIntrinsically disordered regions (IDRs) in DNA-associated proteins are known to influence gene regulation, but their distribution and cooperative functions in genome-wide regulatory programs remain poorly understood.