Rémi Buisson

Jan 3, 2025 | nature.com | Rémi Buisson

AbstractDNA damage in cells induces the expression of inflammatory genes. However, the mechanism by which cells initiate an innate immune response in the presence of DNA lesions blocking transcription remains unknown. Here we find that genotoxic stresses lead to an acute activation of the transcription factor NF-κB through two distinct pathways, each triggered by different types of DNA lesions and coordinated by either ataxia-telangiectasia mutated (ATM) or IRAK1 kinases.

Aug 27, 2024 | nature.com | Yu-Hang Xing |Rémi Buisson |Beverly Naigles |Mary Awad |Raffaele Renella |Edwin Choy | +2 more

AbstractEWS fusion oncoproteins underlie several human malignancies including Desmoplastic Small Round Cell Tumor (DSRCT), an aggressive cancer driven by EWS-WT1 fusion proteins. Here we combine chromatin occupancy and 3D profiles to identify EWS-WT1-dependent gene regulation networks and target genes. We show that EWS-WT1 is a powerful chromatin activator controlling an oncogenic gene expression program that characterizes primary tumors.

Jul 5, 2023 | nature.com | Hideko Isozaki |Ramin Sakhtemani |Sunwoo Oh |Susanna Monroe |Varuna Nangia |Amanda Riley | +10 more

Author notesThese authors contributed equally: Michael S. Lawrence, Aaron N. HataAuthors and AffiliationsMassachusetts General Hospital Cancer Center, Boston, MA, USAHideko Isozaki, Ramin Sakhtemani, Ammal Abbasi, Naveed Nikpour, Marcello Stanzione, Adam Langenbucher, Susanna Monroe, Wenjia Su, Heidie Frisco Cabanos, Faria M. Siddiqui, Nicole Phan, Daria Timonina, Samantha Bilton, Maria Gomez-Caraballo, Hannah L.