Bin Xiao

1 month ago | nature.com | Bin Xiao |Eng-King Tan

A post hoc subgroup analysis has suggested potential therapeutic benefits of prasinezumab, a humanized monoclonal anti-α-synuclein antibody, in patients with rapidly progressing Parkinson’s disease (PD), despite initial trials showing limited impact on primary outcomes. Caution is needed due to the retrospective nature of subgroup analyses, and potential confounding factors that may have influenced the observed treatment effects in specific patient subsets. Critical considerations are provided here for designing and implementing preclinical studies and clinical trials involving monoclonal antibodies, suggesting that future research should prioritize refining preclinical models and optimizing biomarker-based patient selection to reduce risks of false trial outcomes, eventually advancing antibody-based therapies in PD effectively and safely.

Nov 4, 2024 | researchprotocols.org | Bin Xiao

Study Registration Search Strategy Criteria for Studies Types of Studies Types of Participants Types of Interventions Types of Comparators and Controls Outcome Measures Primary Outcome Secondary Outcomes Data Collection and Analysis Selection of Studies Data Extraction and Management Risk of Bias (Quality) Assessment Quality of Evidence Assessment Statistical Analysis Overview Sensitivity Analysis Subgroup Analysis Dealing With Missing Data Assessment of Reporting Bias Principal Findings...

Sep 18, 2024 | pubs.acs.org | Bin Xiao |Jianbo Li |Jun Wang

Feb 28, 2024 | nature.com | Bin Xiao |Eng-King Tan

In two recent articles published in Nature Neuroscience and Cell, Nelson et al.1 and Chen et al.2 have shown that a rare APOE3 Christchurch (APOE3Ch) variant, R136S, has protective effects on neurodegeneration in various Alzheimer’s disease (AD) model systems through attenuating tau pathology and regulating its related neuroimmune responses. Nelson et al. and Chen et al.

Dec 23, 2023 | eprint.iacr.org | Xun Liu |Shang Gao |Tianyu Zheng |Bin Xiao

Paper 2023/1946 , The Hong Kong Polytechnic University, The Hong Kong Polytechnic University, The Hong Kong Polytechnic University, The Hong Kong Polytechnic University The succinct non-interactive argument of knowledge (SNARK) technique is widely used in blockchain systems to replace the costly on-chain computation with the verification of a succinct proof.