Brandon Pickett

2 months ago | nature.com | DongAhn Yoo |Arang Rhie |Prajna hebbar |Francesca Antonacci |Glennis A. Logsdon |Brandon Pickett | +66 more

AbstractThe most dynamic and repetitive regions of great ape genomes have traditionally been excluded from comparative studies1,2,3. Consequently, our understanding of the evolution of our species is incomplete. Here we present haplotype-resolved reference genomes and comparative analyses of six ape species: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan and siamang.

Feb 22, 2024 | biorxiv.org | Kateryna D. Makova |Brandon Pickett |Robert Harris |Gabrielle Hartley

AbstractApes possess two sex chromosomes—the male-specific Y and the X shared by males and females. The Y chromosome is crucial for male reproduction, with deletions linked to infertility1. The X chromosome carries genes vital for reproduction and cognition2. Variation in mating patterns and brain function among great apes suggests corresponding differences in their sex chromosomes.

Dec 1, 2023 | biorxiv.org | Kateryna D. Makova |Brandon Pickett |Robert Harris |Gabrielle Hartley

IntroductionTherian X and Y chromosomes are thought to have originated from a pair of autosomes approximately 170 million years ago (MYA)1. The X chromosome, typically present in two copies in females and one copy in males, has mostly retained the gene content and order from the original autosomal pair2.