Brian J. Levandowski

Jun 7, 2024 | onlinelibrary.wiley.com | Brian J. Levandowski |Brian Graham |Nile Abularrage |Ronald T. Raines

1 INTRODUCTION 5-Membered dienes such as 4H-pyrazoles are rapidly emerging as useful click reagents.1, 2 Spirocyclization provides an effective means to increase the Diels–Alder reactivity of 4H-pyrazoles by circumventing the disrupting effects of geminal repulsion in acyclic geminally substituted 5-membered dienes.3-6 Although 4H-pyrazoles containing five-membered spirocycles have been previously synthesized, they are predicted to be less reactive as Diels–Alder dienes than four-membered...

Sep 25, 2023 | pubs.acs.org | Brian J. Levandowski |Brian Graham |K. N. Houk |Ronald T. Raines

Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Org. Chem. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).

Sep 25, 2023 | dx.doi.org | Brian J. Levandowski |Brian Graham |K. N. Houk |Ronald T. Raines

Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Org. Chem. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).