Nile Abularrage

Jun 7, 2024 | onlinelibrary.wiley.com | Brian J. Levandowski |Brian Graham |Nile Abularrage |Ronald T. Raines

1 INTRODUCTION 5-Membered dienes such as 4H-pyrazoles are rapidly emerging as useful click reagents.1, 2 Spirocyclization provides an effective means to increase the Diels–Alder reactivity of 4H-pyrazoles by circumventing the disrupting effects of geminal repulsion in acyclic geminally substituted 5-membered dienes.3-6 Although 4H-pyrazoles containing five-membered spirocycles have been previously synthesized, they are predicted to be less reactive as Diels–Alder dienes than four-membered...