Byrne C.D

Jul 25, 2024 | cell.com | Byrne C.D |E. Dale Abel |Anna L Gloyn |Joshua Joseph

SummaryDiabetes, a complex multisystem metabolic disorder characterized by hyperglycemia, leads to complications that reduce quality of life and increase mortality. Diabetes pathophysiology includes dysfunction of beta cells, adipose tissue, skeletal muscle, and liver. Type 1 diabetes (T1D) results from immune-mediated beta cell destruction.

Jul 2, 2024 | cell.com | Byrne C.D |O’Byrne S.M |Paul Horn |Campus Virchow-Klinikum

Michalopoulos G.K. Bhushan B. Liver regeneration: biological and pathological mechanisms and implications. Nat. Rev. Gastroenterol. Hepatol. 2021; 18: 40-55https://doi.org/10.1038/s41575-020-0342-4Dechêne A. Sowa J.-P. Gieseler R.K. Jochum C. Bechmann L.P. El Fouly A. Schlattjan M. Saner F. Baba H.A. Paul A. et al. Acute liver failure is associated with elevated liver stiffness and hepatic stellate cell activation. Hepatology.

May 31, 2024 | cell.com | Byrne C.D |O’Byrne S.M |Paul Horn |Campus Virchow-Klinikum

Michalopoulos G.K. Bhushan B. Liver regeneration: biological and pathological mechanisms and implications. Nat. Rev. Gastroenterol. Hepatol. 2021; 18: 40-55https://doi.org/10.1038/s41575-020-0342-4Dechêne A. Sowa J.-P. Gieseler R.K. Jochum C. Bechmann L.P. El Fouly A. Schlattjan M. Saner F. Baba H.A. Paul A. et al. Acute liver failure is associated with elevated liver stiffness and hepatic stellate cell activation. Hepatology.

May 22, 2024 | jbc.org | Byrne C.D |Xuehui Li |Hubei Hongshan Laboratory

AbstractExogenous omega-3 fatty acids, particularly docosahexaenoic acid (DHA), have shown to exert beneficial effects on nonalcoholic fatty liver disease (NAFLD), which is characterized by the excessive accumulation of lipids and chronic injury in the liver. However, the effect of endogenous DHA biosynthesis on the lipid homeostasis of liver is poorly understood.

Feb 29, 2024 | cell.com | Christopher Byrne |Byrne C.D |Lei Miao |Giovanni Targher

HighlightsMetabolic dysfunction-associated steatotic liver disease (MASLD) is now the most widespread global chronic liver disease, affecting over 30% of adults. MASLD has effects beyond adverse liver outcomes, affecting cardiovascular disease, chronic kidney disease, and various extrahepatic cancers. The economic burden of MASLD is substantial, exceeding $100 billion in the USA alone, with liver transplantation being a significant contributor to healthcare costs.