Caroline Lennartsson

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A quantitative and site-specific atlas of the citrullinome reveals widespread existence of citrullination and insights into PADI4 substrates - Nature Structural & Molecular Biology

Feb 6, 2024 | nature.com | Ivo A. Hendriks |Jonas Elsborg |Sara C. Buch-Larsen |Lene Terslev |Alexandra S. Rebak |Caroline Lennartsson

AbstractDespite the importance of citrullination in physiology and disease, global identification of citrullinated proteins, and the precise targeted sites, has remained challenging. Here we employed quantitative-mass-spectrometry-based proteomics to generate a comprehensive atlas of citrullination sites within the HL60 leukemia cell line following differentiation into neutrophil-like cells.

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