Jonas Elsborg

Jun 11, 2024 | nature.com | Henry Cope |Jonas Elsborg |Samuel Demharter |J. McDonald |Chiara Wernecke |Sigrid S. Reinsch | +11 more

AbstractSpaceflight poses a unique set of challenges to humans and the hostile spaceflight environment can induce a wide range of increased health risks, including dermatological issues. The biology driving the frequency of skin issues in astronauts is currently not well understood.

Feb 6, 2024 | nature.com | Ivo A. Hendriks |Jonas Elsborg |Sara C. Buch-Larsen |Lene Terslev |Alexandra S. Rebak |Caroline Lennartsson

AbstractDespite the importance of citrullination in physiology and disease, global identification of citrullinated proteins, and the precise targeted sites, has remained challenging. Here we employed quantitative-mass-spectrometry-based proteomics to generate a comprehensive atlas of citrullination sites within the HL60 leukemia cell line following differentiation into neutrophil-like cells.

Oct 11, 2023 | mdpi.com | Jonas Elsborg |Marco Salvatore

3. Results and DiscussionAs shown in a, we employed a comprehensive approach to study the distinction between healthy and ulcerative colitis samples. To begin, we curated four publicly available datasets on ulcerative colitis, each containing valuable information on the disease. Leveraging the Gut cell atlas, we fine-tuned scBERT, an advanced large language model (LLM), to obtain a detailed and refined cell type annotation, as visualized in b.

Aug 26, 2023 | biorxiv.org | Marco Salvatore |Abzu Aps |Jonas Elsborg

AbstractSingle-cell RNA sequencing (scRNA-seq) technology has significantly advanced our understanding of the diversity of cells and how this diversity is implicated in diseases. Yet, translating these findings across various scRNA-seq datasets poses challenges due to technical variability and dataset-specific biases.