Sara C. Buch-Larsen

Feb 6, 2024 | nature.com | Ivo A. Hendriks |Jonas Elsborg |Sara C. Buch-Larsen |Lene Terslev |Alexandra S. Rebak |Caroline Lennartsson

AbstractDespite the importance of citrullination in physiology and disease, global identification of citrullinated proteins, and the precise targeted sites, has remained challenging. Here we employed quantitative-mass-spectrometry-based proteomics to generate a comprehensive atlas of citrullination sites within the HL60 leukemia cell line following differentiation into neutrophil-like cells.

Jul 18, 2023 | nature.com | Sara C. Buch-Larsen |Abhishek Sharma |Michael Nielsen

AbstractAlthough Poly(ADP-ribose)-polymerases (PARPs) are key regulators of genome stability, how site-specific ADP-ribosylation regulates DNA repair is unclear. Here, we describe a novel role for PARP1 and PARP2 in regulating Rad52-dependent replication fork repair to maintain cell viability when homologous recombination is dysfunctional, suppress replication-associated DNA damage, and maintain genome stability.