Cecile Le Sueur

Jul 27, 2024 | biorxiv.org | Cecile Le Sueur |Magnus Rattray |Mikhail M. Savitski |EMBL Heidelberg

AbstractThermal proteome profiling (TPP) is a proteome wide technology that enables unbiased detection of protein drug interactions as well as changes in post-translational state of proteins between different biological conditions. Statistical analysis of temperature range TPP (TPP-TR) datasets relies on comparing protein melting curves, describing the amount of non-denatured proteins as a function of temperature, between different conditions (e.g. presence or absence of a drug).

Oct 30, 2023 | biorxiv.org | Magnus Rattray |Mikhail M. Savitski |EMBL Heidelberg |Cecile Le Sueur

AbstractThermal proteome profiling (TPP) is a proteome wide technology that enables unbiased detection of protein drug interactions as well as changes in post-translational state of proteins between different biological conditions. Statistical analysis of temperature range TPP (TPP-TR) datasets relies on comparing protein melting curves, describing the amount of non-denatured proteins as a function of temperature, between different conditions (e.g. presence or absence of a drug).