Magnus Rattray

Jan 15, 2025 | onlinelibrary.wiley.com | Stephen Eyre |Magnus Rattray |Andrew Morris |Inti Pagnuco

1 Introduction Genome-wide association studies (GWAS) have successfully identified regions of the genome associated with complex human traits and diseases. However, the identification of causal genes and the understanding of the biological mechanisms underpinning these associations often remain unclear (Visscher et al. 2012).

Dec 4, 2024 | biorxiv.org | Qian Zhao |Magnus Rattray

AbstractBackground: Many popular single-cell and spatial transcriptomics platforms exhibit 3′ bias, making it challenging to resolve all transcripts but potentially more feasible to resolve alternative polyadenylation (APA) events. Despite the development of several tools for identifying APA events in scRNA-seq data, a neutral benchmark is lacking, complicating the choice for biologists.

Jul 27, 2024 | biorxiv.org | Cecile Le Sueur |Magnus Rattray |Mikhail M. Savitski |EMBL Heidelberg

AbstractThermal proteome profiling (TPP) is a proteome wide technology that enables unbiased detection of protein drug interactions as well as changes in post-translational state of proteins between different biological conditions. Statistical analysis of temperature range TPP (TPP-TR) datasets relies on comparing protein melting curves, describing the amount of non-denatured proteins as a function of temperature, between different conditions (e.g. presence or absence of a drug).

Oct 30, 2023 | biorxiv.org | Magnus Rattray |Mikhail M. Savitski |EMBL Heidelberg |Cecile Le Sueur

AbstractThermal proteome profiling (TPP) is a proteome wide technology that enables unbiased detection of protein drug interactions as well as changes in post-translational state of proteins between different biological conditions. Statistical analysis of temperature range TPP (TPP-TR) datasets relies on comparing protein melting curves, describing the amount of non-denatured proteins as a function of temperature, between different conditions (e.g. presence or absence of a drug).