EMBL Heidelberg

Jul 27, 2024 | biorxiv.org | Cecile Le Sueur |Magnus Rattray |Mikhail M. Savitski |EMBL Heidelberg

AbstractThermal proteome profiling (TPP) is a proteome wide technology that enables unbiased detection of protein drug interactions as well as changes in post-translational state of proteins between different biological conditions. Statistical analysis of temperature range TPP (TPP-TR) datasets relies on comparing protein melting curves, describing the amount of non-denatured proteins as a function of temperature, between different conditions (e.g. presence or absence of a drug).

Mar 6, 2024 | pressebox.com | EMBL Heidelberg

(PresseBox) () A new EMBL study reveals how the cancer-promoting MAGE family of proteins bind to their targets, aiding the development of anti-cancer drugs that target these proteins. The results of the study, published in The EMBO Journal, could potentially help in the development of drugs against certain chemotherapy- and radiotherapy-resistant cancers.

Mar 6, 2024 | pressebox.de | EMBL Heidelberg

(PresseBox) () A new EMBL study reveals how the cancer-promoting MAGE family of proteins bind to their targets, aiding the development of anti-cancer drugs that target these proteins. The results of the study, published in The EMBO Journal, could potentially help in the development of drugs against certain chemotherapy- and radiotherapy-resistant cancers.

Dec 24, 2023 | academic.oup.com | EMBL Heidelberg

In all three domains of life, post-transcriptional regulation of mRNA by small regulatory RNA (sRNA) represents an important mechanism to fine tune the flow of genetic information. In gram-negative bacteria such as Escherichia coli, sRNAs post-transcriptionally regulate more than half of all mRNAs, and many of these interactions are facilitated by the activity of an RNA binding protein (RBP), especially Hfq and ProQ (1–4). Hfq is a hexameric Sm/Lsm-type RBP that is conserved in many bacteria.

Dec 14, 2023 | pressebox.com | EMBL Heidelberg

Former EMBL staff scientist founds a start-up – DenovAI – for broader, faster and cheaper antibody discovery using advanced machine learning and computational biophysicsAntibodies are an important tool in the human immune system’s arsenal against disease. They attach to bacteria, viruses, fungi, or toxins, marking them for destruction or removal from the body.