Charlotte Buckley

Jun 5, 2024 | onlinelibrary.wiley.com | Jennifer Boyd |John Holmes |Naomi Gibbs |Charlotte Buckley

1 INTRODUCTION Alcohol consumption is a leading cause of death, disease and disability globally [1, 2]. Targeted price-based interventions, for instance, minimum unit pricing (MUP), can reduce alcohol consumption, and as a result alcohol-related morbidity and mortality [3-6]. MUP sets a legal ‘floor price’ below which retailers cannot sell a particular volume of pure alcohol to consumers [3].

Apr 23, 2024 | bpspubs.onlinelibrary.wiley.com | Charlotte Buckley |Matthew Lee |xun zhang |Calum Wilson

AM acetoxymethyl ester EGTA ethylene glycol tetra-acetic acid FRAP Fluorescent recovery after photobleaching NP nitrophenyl PPs physiological saline solution What is already known Endothelial cells are specialized to detect specific stimuli and control virtually all cardiovascular activities. Communication across endothelial cells shares information so that a coordinated cardiovascular response occurs.

Mar 29, 2024 | biorxiv.org | xun zhang |Charlotte Buckley |Matthew Lee |Margaret MacDonald

AbstractBackground: Endothelial cell TRPV4 channels provide a control point that is pivotal in regulating blood vessel diameter by mediating the Ca2+-dependent release of endothelial-derived vasoactive factors. In hypertension, TRPV4-mediated control of vascular function is disrupted but the underlying mechanisms, and precise physiological consequences remain controversial.