Jessica B. Spinelli

Jan 13, 2025 | nature.com | Beatriz Cicuéndez |Juan Lopez |Juan López |Andrea Curtabbi |Javier Perez-Garcia |Daniel Jimenez-Blasco | +15 more

AbstractObesity poses a global health challenge, demanding a deeper understanding of adipose tissue (AT) and its mitochondria. This study describes the role of the mitochondrial protein Methylation-controlled J protein (MCJ/DnaJC15) in orchestrating brown adipose tissue (BAT) thermogenesis. Here we show how MCJ expression decreases during obesity, as evident in human and mouse adipose tissue samples.

Nov 21, 2024 | biorxiv.org | Alexandra Byrne |Lauren O'Connor |Paula Vo |Jessica B. Spinelli

AbstractEmerging evidence suggests the microbiome critically influences the onset and progression of neurodegenerative diseases; however, the identity of neuroprotective bacteria and the molecular mechanisms that respond within the host remain largely unknown.

Oct 25, 2023 | nature.com | Rui Li |Lihua Zhu |Christopher Ashwood |Karl Simin |Cholsoon Jang |Jessica B. Spinelli | +1 more

AbstractIdentifying metabolic steps that are specifically required for the survival of cancer cells but are dispensable in normal cells remains a challenge1. Here we report a therapeutic vulnerability in a sugar nucleotide biosynthetic pathway that can be exploited in cancer cells with only a limited impact on normal cells.

Oct 25, 2023 | nature.com | Rui Li |Lihua Zhu |Christopher Ashwood |Karl Simin |Cholsoon Jang |Jessica B. Spinelli | +1 more

AbstractIdentifying metabolic steps that are specifically required for the survival of cancer cells but are dispensable in normal cells remains a challenge1. Here we report a therapeutic vulnerability in a sugar nucleotide biosynthetic pathway that can be exploited in cancer cells with only a limited impact on normal cells.