Christian-Albrechts-University Kiel

Oct 15, 2024 | onlinelibrary.wiley.com | Sandrine Jayne |Cristina Lopez |Cristina Conde López |Christian-Albrechts-University Kiel |Natalie Put

INTRODUCTION Unlike other lymphoid malignancies, balanced, reciprocal chromosomal translocations are rare in chronic lymphocytic leukaemia (CLL).1 However, chromosomal translocation t(1;6)(p35.3;p25.2) has been previously described as a rare but recurrent event.2-5 The presence of this translocation in 12 previously reported cases of CLL has been associated with high-risk chromosomal aberrations like del(11q) and del(17p), unmutated IGHV status and a progressive clinical course (for review,...

May 21, 2024 | link.springer.com | Christian-Albrechts-University Kiel

AbstractProteins delivered by endocytosis or autophagy to lysosomes are degraded by exo- and endoproteases. In humans 15 lysosomal cathepsins (CTS) act as important physiological regulators. The cysteine proteases CTSB and CTSL and the aspartic protease CTSD are the most abundant and functional important lysosomal proteinases.

Apr 22, 2024 | link.springer.com | Christian-Albrechts-University Kiel |KU Leuven

AbstractThe laterality of motor symptoms is considered a key feature of Parkinson’s disease (PD). Here, we investigated whether gait and turning asymmetry coincided with symptom laterality as determined by the MDS-UPRDS part III and whether it was increased compared to healthy controls (HC).

Feb 6, 2024 | academic.oup.com | Paediatric Haematology |Christian-Albrechts-University Kiel |Paediatric Endocrinology |Justus Liebig

Adrenocortical carcinomas are very rare malignancies in childhood associated with poor outcome in advanced disease. Most adrenocortical tumors (ACT) are functional, causing signs and symptoms of adrenal hormone excess. In most studies, endocrine manifestations were reported 4 to 6 months prior to diagnosis. We sought to extend knowledge on endocrine manifestations with regard to age and sex to facilitate early diagnosis.

Jun 23, 2023 | journals.aai.org | Christian-Albrechts-University Kiel

Activation of the complement system represents an important effector mechanism of endogenous and therapeutic Abs. However, efficient complement activation is restricted to a subset of Abs due to the requirement of multivalent interactions between the Ab Fc regions and the C1 complex. In the present study, we demonstrate that Fc-independent recruitment of C1 by modular bispecific single-domain Abs that simultaneously bind C1q and a surface Ag can potently activate the complement system.