Christian Cuba Samaniego

Nov 29, 2024 | biorxiv.org | Frank Britto Bisso |Giulia Giordano |Christian Cuba Samaniego |Carnegie Mellon

AbstractEngineering cell fate is fundamental for optimizing stem cell-based therapies aimed at replacing cells in patients suffering from trauma or disease. By timely administering molecular regulators - such as transcription factors, RNAs, or small molecules - in a process that mimics in vivo embryonic development, stem cell differentiation can be guided toward a specific cell fate.

Jul 21, 2023 | onlinelibrary.wiley.com | Christian Cuba Samaniego |Jay Friedman |Xinping Yang |Christopher Badger

Abstract Background Treatment of patients with newly diagnosed HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) with neoadjuvant chemotherapy (NAC) results in a high rate of 5-year recurrence free survival with few patients requiring adjuvant treatment. We hypothesized that NAC enhances primary tumor HPV-specific T cell responses. Methods HPV-specific responses in tumor infiltrating lymphocytes (TILs) before and after NAC were determined using autologous co-culture assays.