Giulia Giordano

Feb 11, 2025 | biorxiv.org | Eiji Nakamura |Franco Blanchini |Giulia Giordano |Alexander Hoffmann

AbstractCells have the capacity to encode and decode information in the temporal features of molecular signals. Many pathways, for example, generate either sustained or pulsatile responses depending on the context, and such diverse temporal behaviors have a profound impact on cell fate. Here we focus on how molec- ular pathways can convert the temporal features of dynamic signals, in particular how they can convert transient signals into persistent downstream events and vice versa.

Dec 4, 2024 | nature.com | Giulia Giordano

AbstractThe magnitude of benefit of Mediterranean diet in cancer prevention and mortality in older adults is still unclear, therefore we conducted a systematic review and meta-analysis. Outcomes considered were cancer incidence and cancer mortality. In studies evaluating cancer incidence as a time-to-event endpoint and adherence as quantiles, HR was 0.885 (95% CI 0.773–1.013, I2 = 44%).

Nov 29, 2024 | biorxiv.org | Frank Britto Bisso |Giulia Giordano |Christian Cuba Samaniego |Carnegie Mellon

AbstractEngineering cell fate is fundamental for optimizing stem cell-based therapies aimed at replacing cells in patients suffering from trauma or disease. By timely administering molecular regulators - such as transcription factors, RNAs, or small molecules - in a process that mimics in vivo embryonic development, stem cell differentiation can be guided toward a specific cell fate.