Christoph F. Kollmann

Mar 6, 2024 | nature.com | Qi Wu |Rasmus O. Bak |Søren R. Paludan |Christoph F. Kollmann |Trine I. Jensen |Bao-cun Zhang

AbstractDNA is a danger signal sensed by cGAS to engage signaling through STING to activate innate immune functions. The best-studied downstream responses to STING activation include expression of type I interferon and inflammatory genes, but STING also activates other pathways, including apoptosis. Here, we report that STING-dependent induction of apoptosis in macrophages occurs through the intrinsic mitochondrial pathway and is mediated via IRF3 but acts independently of gene transcription.