Søren R. Paludan

Jul 24, 2024 | nature.com | Yi-Hao Chan |zhiyong Liu |Paul Bastard |Oliver Harschnitz |Peng Zhang |Gabriele Ciceri | +14 more

AbstractMost cases of herpes simplex virus 1 (HSV-1) encephalitis (HSE) remain unexplained1,2. Here, we report on two unrelated people who had HSE as children and are homozygous for rare deleterious variants of TMEFF1, which encodes a cell membrane protein that is preferentially expressed by brain cortical neurons. TMEFF1 interacts with the cell-surface HSV-1 receptor NECTIN-1, impairing HSV-1 glycoprotein D- and NECTIN-1-mediated fusion of the virus and the cell membrane, blocking viral entry.

Mar 28, 2024 | nature.com | Bao-cun Zhang |Ryo Narita |Aida S Hansen |Jinrong Huang |Emil K Nilsson |Christina Zeiler | +6 more

AbstractThe cGAS-STING pathway plays a crucial role in anti-tumoral responses by activating inflammation and reprogramming the tumour microenvironment. Upon activation, STING traffics from the endoplasmic reticulum (ER) to Golgi, allowing signalling complex assembly and induction of interferon and inflammatory cytokines. Here we report that cGAMP stimulation leads to a transient decline in ER cholesterol levels, mediated by Sterol O-Acyltransferase 1-dependent cholesterol esterification.

Mar 6, 2024 | nature.com | Qi Wu |Rasmus O. Bak |Søren R. Paludan |Christoph F. Kollmann |Trine I. Jensen |Bao-cun Zhang

AbstractDNA is a danger signal sensed by cGAS to engage signaling through STING to activate innate immune functions. The best-studied downstream responses to STING activation include expression of type I interferon and inflammatory genes, but STING also activates other pathways, including apoptosis. Here, we report that STING-dependent induction of apoptosis in macrophages occurs through the intrinsic mitochondrial pathway and is mediated via IRF3 but acts independently of gene transcription.

Mar 13, 2023 | nature.com | Søren R. Paludan

Cite this articleAssil, S., Paludan, S.R. STING is ESCRTed to degradation by microautophagy. Nat Cell Biol 25, 379–380 (2023). https://doi.org/10.1038/s41556-022-01084-7Download citationPublished: 13 March 2023Issue Date: March 2023DOI: https://doi.org/10.1038/s41556-022-01084-7Share this articleAnyone you share the following link with will be able to read this content:Sorry, a shareable link is not currently available for this article.