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Jan 16, 2025 | 
orientxxi.info | Robin Beaumont
El 3 de diciembre de 2024, mientras la oposición armada siria liderada por la Organización para la Liberación del Levante Hayat Tahrir al-Sham (HTS), que ya controlaba Alepo, se preparaba para la toma de Hama, el primer ministro iraquí, Mohammed Shia’ al-Sudani, llamó al presidente de Turquía, Recep Tayyip Erdogan, considerado como cercano al grupo HTS, para advertirle: “Irak no será un simple espectador de las graves repercusiones de los hechos acaecidos en Siria”.
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Jan 7, 2025 | 
orientxxi.info | Robin Beaumont
On 3 December 2024, when the armed Syrian opposition, led by Hayat Tahrir al-Sham (HTS), which had already taken Aleppo, was preparing to storm Hama, Iraqi Prime Minister, Mohammed Shia’ al-Sudani, made a phone call to Turkish President Recep Tayyip Erdoğan, generally regarded as close to HTS, with a warning: “Iraq will not be a passive spectator of the serious repercussions of events in Syria.” Two weeks later, when the Syrian regime had collapsed and Bashar al-Assad was in exile, it seems...
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May 30, 2024 | 
orientxxi.info | Robin Beaumont
La naissance, la proclamation et la défaite du «califat» de l’organisation de l’État islamique (OEI) — ou Daech 1 — sur une partie des territoires irakien et syrien au cours des années 2010 ont suscité une littérature considérable. Celle-ci s’est principalement penchée sur ses implications géopolitiques, ainsi que sur les attaques terroristes conduites en son nom dans le monde entier, et sur la guerre qui a conduit à sa chute entre 2014 et 2017.
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Apr 26, 2024 | 
genomemedicine.biomedcentral.com | Robin Beaumont |Gareth Hawkes |Adam C Gunning |Caroline Wright
Variants from exome sequencing (ES) data within the UK Biobank were called centrally by the UKB team using graphTyper [19]. We used the Ensembl VEP v104 [20] with the LOFTEE plugin [15] to annotate the variants with their predicted functional consequences. We excluded variants which were flagged for removal by UKB due to low depth based on 90% of calls having depth < 10.
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Nov 20, 2023 | 
biorxiv.org | Gareth Hawkes |Robin Beaumont |Zilin Li |Ravi Mandla
AbstractThe role of rare non-coding variation in complex human phenotypes is still largely unknown. To elucidate the impact of rare variants in regulatory elements, we performed a whole-genome sequencing association analysis for height using 333,100 individuals from three datasets: UK Biobank (N=200,003), TOPMed (N=87,652) and All of Us (N=45,445).
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Oct 12, 2023 | 
medrxiv.org | Robin Beaumont |Gareth Hawkes |Adam C Gunning |Caroline Wright
The authors have declared no competing interest. This work was supported by the Medical Research Council [MR/T00200X/1]I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
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Oct 5, 2023 | 
nature.com | Robin Beaumont |Christopher Flatley |Marc Vaudel |JING CHEN |Gunn-Helen Moen |Line Skotte | +52 more
AbstractA well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1.
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Jun 22, 2023 | 
nature.com | Saleh Shekari |Stasa Stankovic |Eugene J. Gardner |Gareth Hawkes |Katherine A. Kentistou |Robin Beaumont | +6 more
Author notesThese authors contributed equally: Saleh Shekari, Stasa Stankovic, John R. B. Perry, Anna Murray. Authors and AffiliationsDepartment of Clinical and Biomedical Sciences, University of Exeter, Exeter, UKSaleh Shekari, Gareth Hawkes, Robin N. Beaumont, Andrew R. Wood, Caroline F. Wright, Michael N. Weedon, Katherine S. Ruth & Anna MurraySchool of Public Health, Faculty of Medicine, University of Queensland, Brisbane, Queensland, AustraliaSaleh Shekari & Gita D.
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May 10, 2023 | 
nature.com | Pol Sole-Navais |Valgerdur Steinthorsdottir |Marc Vaudel |Julius Juodakis |JING CHEN |Triin Laisk | +40 more
Author notesAnubha Mahajan & Mark I. McCarthyPresent address: Genentech, South San Francisco, CA, USAThese authors contributed equally: Ge Zhang, Bo Jacobsson.
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Apr 3, 2023 | 
nature.com | Pol Sole-Navais |Valgerdur Steinthorsdottir |Marc Vaudel |Julius Juodakis |JING CHEN |Triin Laisk | +40 more
AbstractThe timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic basis remains largely unresolved. We present a maternal genome-wide meta-analysis of gestational duration (n = 195,555), identifying 22 associated loci (24 independent variants) and an enrichment in genes differentially expressed during labor. A meta-analysis of preterm delivery (18,797 cases, 260,246 controls) revealed six associated loci and large genetic similarities with gestational duration.
