CHU Lille

Jan 20, 2025 | academic.oup.com | Univ. Lille |CHU Lille

The gastrointestinal tract is a remarkable example of complex biology, with a constant dialogue between the intestinal epithelium, in close contact with the microbiota, and the immune cells that protect the gut from infection. Organoids have revolutionized our approach to modelling the intestinal cellular compartment and have opened new avenues for unravelling the mechanisms involved in intestinal homeostasis and chronic pathogenesis such as inflammatory bowel disease.

Jan 14, 2025 | academic.oup.com | CHU Lille |CHU Bordeaux |Univ. Lille

Unlike X-linked or autosomal recessive Alport Syndrome, no clear genotype/phenotype correlation has yet been demonstrated in patients carrying a single variant of COL4A3 or COL4A4. We carried out a multicenter retrospective study to assess the risk factors involved in renal survival in patients presenting a single pathogenic variant on COL4A3 or COL4A4. 97 patients presenting a single pathogenic variant of COL4A3 or COL4A4 were included.

Dec 4, 2024 | rbej.biomedcentral.com | CHU Lille

This study retrospectively analysed all oocyte donation cycles performed between July 2018 and July 2022 in the Department of Reproductive Medicine at the University Hospital of Lille, France. All the donors were younger than 38 years and were recruited by the same referring physician. Donors were systematically evaluated for contraindications such as hereditary conditions or contraindications to controlled ovarian stimulation.

Dec 4, 2024 | nsojournals.onlinelibrary.wiley.com | Shira Houwenhuyse |François Massol |Univ. Lille |CHU Lille

Introduction Interspecific competitive interactions can play an important structuring role in communities via their effects on organismal growth and survival. An often-overlooked factor regarding how such interactions may shape life-history traits is through the microbiota associated with the competing host species (Augustin et al. 2017). Microbiota can contribute to host fitness by affecting host digestion, metabolism, growth and immunity (Franzenburg et al. 2013, Motiei et al. 2020).

Nov 29, 2024 | link.springer.com | CHU Lille |Univ. Lille

AbstractOvarian tissue cryopreservation (OTC) is recommended by scientific societies for women undergoing highly gonadotoxic cancer treatments. Following transplantation, the restoration of ovarian function is typically characterised by the resumption of spontaneous menstruation. Yet, a few studies have looked at the longitudinal hormonal variations following transplantation.