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2 months ago | 
publications.ersnet.org | Alvar Agusti |Stefano Aliberti |Pieve Emanuele |Francesco Blasi
Editorial Occluding mucous airway plugs in patients with obstructive lung diseases: a new treatable trait? ArticleFigures & TablesInfo & Metrics Chronic mucous hypersecretion (CMH), often manifested clinically by chronic productive cough (i.e. chronic bronchitis), is a well-described feature in several obstructive lung diseases, including asthma, COPD and bronchiectasis.
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Oct 29, 2024 | 
bmcpulmmed.biomedcentral.com | De Angelis |Pieve Emanuele
ReferencesBruserud Ø, Oftedal BE, Wolff AB, Husebye ES. AIRE-mutations and autoimmune disease. Curr Opin Immunol. 2016;43:8–15. https://doi.org/10.1016/j.coi.2016.07.003. Article CAS PubMed Google Scholar Anderson MS, Su MA. AIRE expands: new roles in immune tolerance and beyond. Nat Rev Immunol. 2016;16(4):247–58. https://doi.org/10.1038/nri.2016.9.Article CAS PubMed PubMed Central Google Scholar Ahonen P, Myllärniemi S, Sipilä I, Perheentupa J.
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Oct 22, 2024 | 
academic.oup.com | Rheumazentrum Ruhrgebiet |Ruhr Bochum |Pieve Emanuele
Evaluate guselkumab efficacy, an anti-interleukin-23p19-subunit antibody, in patients with active psoriatic arthritis (PsA) and inadequate response to 1–2 tumour necrosis factor inhibitors (TNFi-IR), utilizing composite indices assessing disease activity across disease domains. In the Phase IIIb COSMOS trial, 285 adults with TNFi-IR PsA were randomized (2:1) to receive guselkumab 100 mg or placebo at Week (W)0, W4, then every 8 weeks through W44.
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Aug 23, 2024 | 03292-9/fulltext?rss=yes&sz=64)
redjournal.org | Pieve Emanuele |Bobby Shayegan |CHU Lille
Keywords bladder cancer radiotherapy Transurethral Resection Survival Analysis Abbreviations NAC (neoadjuvant chemotherapy) RC (radical cystectomy) cM0 (non-metastatic) MIBC (muscle-invasive bladder cancer) BSP (bladder sparing protocols) TURBT (transurethral resection of the bladder) pT (pathological tumor) CR (complete response) OS (overall survival) RT (radiotherapy) cT (clinical tumor) cN (clinical lymph node) TMT (trimodal therapy) DFS (disease-free survival) MFS (metastasis-free...
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May 11, 2024 | 
academic.oup.com | Pieve Emanuele
Accepted manuscripts are PDF versions of the author’s final manuscript, as accepted for publication by the journal but prior to copyediting or typesetting. They can be cited using the author(s), article title, journal title, year of online publication, and DOI. They will be replaced by the final typeset articles, which may therefore contain changes. The DOI will remain the same throughout.
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May 10, 2024 | 
link.springer.com | Pieve Emanuele
This is a preview of subscription content, to check access. Price excludes VAT (USA) Tax calculation will be finalised during checkout. Instant access to the full article PDF. Rent this article via DeepDyve ReferenceFundingThe author received no financial support for the authorship and/or publication of the present article.
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Apr 1, 2024 | 
ccforum.biomedcentral.com | Pieve Emanuele
This meta-analysis included the latest evidence and found that individualized PEEP titration by lung compliance was associated with a reduced risk of a composite of postoperative pulmonary complications compared with fixed PEEP. Subgroup analyses suggested that the association was evident in the subgroup with PEEP titration by dynamic compliance or stepwise decremental strategy.
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Feb 12, 2024 | 
karger.com | Pieve Emanuele
Keywords:
Citrate,
Calcium,
Continuous renal replacement therapy,
Metformin,
Mitochondria
Dear Editor,
we recently described 3 patients treated with continuous renal replacement therapy (CRRT) for acute kidney injury with metformin accumulation and severe metabolic acidosis [1]. Metformin accumulation partly inhibits mitochondrial metabolism in the liver and other tissues [2‒4], so it could also impair (mitochondrial) citrate clearance.
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Nov 3, 2023 | 00343-8/abstract&sz=64)
resmedjournal.com | Andrea Gramegna |Stefano Aliberti |Pieve Emanuele |Maria Calderazzo
The advent of elexacaftor/tezacaftor/ivacaftor (ETI) resulted in unprecedented clinical benefits for eligible adults with CF. As a result, the question of whether chronic treatments can be safely stopped or adapted to this new situation has become a matter of great interest. Our objective was to derive a consensus among Italian experts on the impact of ETI on the current clinical management of CF lung disease.
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Nov 2, 2023 | 
academic.oup.com | Pieve Emanuele
Fistulas are a debilitating complication of Crohn’s disease (CD). We conducted a systematic review to assess the efficacy of medical therapies for fistulising CD. MEDLINE, Embase, and CENTRAL were searched on May 26, 2022, for randomised controlled trials (RCTs) of pharmacologic therapy in adults with fistulising CD. The primary outcome was induction and maintenance of fistula response. Pooled risk ratios (RRs) and 95% confidence intervals (CI) were calculated.
