Chuangye Qi

Jun 3, 2024 | digitalcommons.library.tmc.edu | Xiaoyu Zhu |Chuangye Qi |Ruoyu Wang |Joo-Hyung Lee

The nuclear pore complex (NPC) comprises more than 30 nucleoporins (NUPs) and is a hallmark of eukaryotes. NUPs have been suggested to be important in regulating gene transcription and 3D genome organization. However, evidence in support of their direct roles remains limited. Here, by Cut&Run, we find that core NUPs display broad but also cell-type-specific association with active promoters and enhancers in human cells.