Joo-Hyung Lee

Jun 3, 2024 | digitalcommons.library.tmc.edu | Xiaoyu Zhu |Chuangye Qi |Ruoyu Wang |Joo-Hyung Lee

The nuclear pore complex (NPC) comprises more than 30 nucleoporins (NUPs) and is a hallmark of eukaryotes. NUPs have been suggested to be important in regulating gene transcription and 3D genome organization. However, evidence in support of their direct roles remains limited. Here, by Cut&Run, we find that core NUPs display broad but also cell-type-specific association with active promoters and enhancers in human cells.

May 24, 2024 | digitalcommons.library.tmc.edu | Ruoyu Wang |Joo-Hyung Lee |Jieun Kim |Feng Xiong

AbstractSome viruses restructure host chromatin, influencing gene expression, with implications for disease outcome. Whether this occurs for SARS-CoV-2, the virus causing COVID-19, is largely unknown. Here we characterized the 3D genome and epigenome of human cells after SARS-CoV-2 infection, finding widespread host chromatin restructuring that features widespread compartment A weakening, A-B mixing, reduced intra-TAD contacts and decreased H3K27ac euchromatin modification levels.

Jul 12, 2023 | newsdirectory3.com | Joo-Hyung Lee

Teenage High School Student Booked for Classmate’s Murder in DaejeonExecution time: 2023-07-12 19:41Daejeon Dunsan Police Station[Yonhap NewsTV Capture]A high school student in Daejeon has been booked and investigated by the Daejeon Dunsan Police Station for the murder of her classmate. The incident took place at the victim’s house in Seo-gu, Daejeon at around 12:00 noon on the 12th. The suspect, identified as Miss A (17), allegedly strangled Miss B (17) during a visit to her house.