Chun-Qing Song

Dec 18, 2024 | mdpi.com | Chun-Qing Song

2. Materials and Methods 2.1. Data AcquisitionThe flowchart of this study, depicted in Figure S1, delineates the data analysis process. Gene sequence data and clinical information for 374 HCC samples were obtained from the TCGA database (https://cancergenome.nih.gov/, accessed on 7 November 2023). We also downloaded HCC transcriptional profiling data from GSE14520 [30,31] with two different platforms in the GEO (https://www.ncbi.nlm.nih.gov/, accessed on 7 November 2023).

Apr 24, 2024 | nature.com | Zhiqing Li |Huilin Niu |Miao Gui |Shikui Tu |Zhao Zhang |Chun-Qing Song | +2 more

AbstractThe PIWI-interacting RNA (piRNA) pathway is an adaptive defense system wherein piRNAs guide PIWI family Argonaute proteins to recognize and silence ever-evolving selfish genetic elements and ensure genome integrity. Driven by this intensive host–pathogen arms race, the piRNA pathway and its targeted transposons have coevolved rapidly in a species-specific manner, but how the piRNA pathway adapts specifically to target silencing in mammals remains elusive.