Shikui Tu

Apr 24, 2024 | nature.com | Zhiqing Li |Huilin Niu |Miao Gui |Shikui Tu |Zhao Zhang |Chun-Qing Song | +2 more

AbstractThe PIWI-interacting RNA (piRNA) pathway is an adaptive defense system wherein piRNAs guide PIWI family Argonaute proteins to recognize and silence ever-evolving selfish genetic elements and ensure genome integrity. Driven by this intensive host–pathogen arms race, the piRNA pathway and its targeted transposons have coevolved rapidly in a species-specific manner, but how the piRNA pathway adapts specifically to target silencing in mammals remains elusive.

Mar 3, 2023 | journals.plos.org | Peng Zhang |Shanghai Jiao Tong |Shikui Tu

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. AbstractAccurate prediction of synergistic effects of drug combinations can reduce the experimental costs for drug development and facilitate the discovery of novel efficacious combination therapies for clinical studies. The drug combinations with high synergy scores are regarded as synergistic ones, while those with moderate or low synergy scores are additive or antagonistic ones.