Miao Gui

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Mammalian PIWI–piRNA–target complexes reveal features for broad and efficient target silencing - Nature Structural & Molecular Biology

Apr 24, 2024 | nature.com | Zhiqing Li |Huilin Niu |Miao Gui |Shikui Tu |Zhao Zhang |Chun-Qing Song | +2 more

AbstractThe PIWI-interacting RNA (piRNA) pathway is an adaptive defense system wherein piRNAs guide PIWI family Argonaute proteins to recognize and silence ever-evolving selfish genetic elements and ensure genome integrity. Driven by this intensive host–pathogen arms race, the piRNA pathway and its targeted transposons have coevolved rapidly in a species-specific manner, but how the piRNA pathway adapts specifically to target silencing in mammals remains elusive.

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