Chuwen Liu

Oct 3, 2024 | biorxiv.org | Yu Zhang |Tianyi Liu |Chuwen Liu |Xuejun Sun

AbstractBackgroundViral respiratory infections are a significant global health burden. Human immune responses to infections caused by respiratory viruses are complex and dependent on the length of time the host has been infected. Human viral challenge studies provide a useful opportunity to understand the timing of human immune responses as samples can be obtained pre-inoculation and post-inoculation by defined virus inocula.

Oct 2, 2024 | biorxiv.org | Xuejun Sun |Yu An Zhang |Chuwen Liu |Xiaojing Zheng

AbstractIntegrated analysis of human gene expression data from multiple studies has become essential in genomics research for complex traits. However, integrating data generated from different cohorts with different platforms, such as microarray and RNA-seq, often requires data preprocessing, including normalization. In this study, we empirically evaluate 9 commonly used cross-platform normalization methods. We classify these methods into two main types: joint and separate normalization.