Xiaojing Zheng

Oct 2, 2024 | biorxiv.org | Xuejun Sun |Yu An Zhang |Chuwen Liu |Xiaojing Zheng

AbstractIntegrated analysis of human gene expression data from multiple studies has become essential in genomics research for complex traits. However, integrating data generated from different cohorts with different platforms, such as microarray and RNA-seq, often requires data preprocessing, including normalization. In this study, we empirically evaluate 9 commonly used cross-platform normalization methods. We classify these methods into two main types: joint and separate normalization.